Search results for " insulin-resistance"
showing 5 items of 5 documents
Long-term parameters of heart rate variability in patients with insulin-resistance.
2019
Heart rate variability (HRV) is defined as the oscillation in both the interval between consecutive heartbeats (considered RR intervals) and consecutives measures of instantaneous heart rates.1 HRV measures the cardiac autonomic function noninvasively1,2 and its reduction is an independent risk factor for cardiovascular events.3 Insulin-resistance is a pathological condition, in which the body’s cells become resistant to insulin effects.4 The aim of our study was to evaluate the relationship between insulin-resistance and the reduction of HRV parameters.
Die Bedeutung von Magnesium für Insulinresistenz, metabolisches Syndrom und Diabetes mellitus - Empfehlungen der Gesellschaft für Magnesium-Forschung…
2014
Mangel an Magnesium (Mg) ist ein wichtiges und haufiges Begleitphanomen bei Patienten mit Diabetes mellitus oder Vorstufen eines Diabetes Typ 2 wie dem Metabolischen Syndrom. Mg-Mangel erhoht das Risiko, einen Diabetes Typ 2 zu entwickeln. Diese Empfehlungen resumieren die gegenwartigen Kenntnisse zur Physiologie des Mg im Kohlenhydratstoffwechsel und die pathophysiologischen Folgen des Mg-Mangels bei Diabetikern. Diabetiker und Patienten mit dessen Vorstufen profitieren von vier Kategorien der Mg-Wirkmechanismen: Insulin-sensitizing-Effekt, Ca-Antagonismus, Stress-Regulation und Endothel-stabilisierender Effekt. Klinische Studiendaten mit Mg-Comedikation zeigen verminderte Insulinresistenz…
Lipidomic profiling identifies signatures of metabolic risk
2020
Background: Metabolic syndrome (MetS), the clustering of metabolic risk factors, is associated with cardiovascular disease risk. We sought to determine if dysregulation of the lipidome may contribute to metabolic risk factors. Methods: We measured 154 circulating lipid species in 658 participants from the Framingham Heart Study (FHS) using liquid chromatography-tandem mass spectrometry and tested for associations with obesity, dysglycemia, and dyslipidemia. Independent external validation was sought in three independent cohorts. Follow-up data from the FHS were used to test for lipid metabolites associated with longitudinal changes in metabolic risk factors. Results: Thirty-nine lipids were…
Metabolic syndrome triggered by high-fructose diet favors choroidal neovascularization and impairs retinal light sensitivity in the rat
2014
Diabetic retinopathy and age-related macular degeneration are the leading causes of blindness in Western populations. Although it is a matter of controversy, large-scale population-based studies have reported increased prevalence of age-related macular degeneration in patients with diabetes or diabetic retinopathy. We hypothesized that metabolic syndrome, one of the major risk factors for type 2 diabetes, would represent a favorable environment for the development of choroidal neovascularization, the main complication of age-related macular degeneration. The fructose-fed rat was used as a model for metabolic syndrome in which choroidal neovascularization was induced by laser photocoagulatio…
Liver and pancreatic fat content and metabolism in healthy monozygotic twins with discordant physical activity
2011
Background & Aims: Ectopic fat in muscle and liver is linked to obesity and type 2 diabetes. Recently, pancreatic lipid accumulation has also been associated with beta-cell dysfunction and reduced insulin production, leading to the development of type 2 diabetes. Physical exercise training has been shown to attenuate beta-cell dysfunction in patients, but little is known about its effects on pancreatic and hepatic fat accumulation. In this study, we validated in-vivo proton magnetic resonance spectroscopy ((1)H MRS) in pancreatic fat measurement with biochemical measurements in a pig model. Thereafter, the effects of increased physical activity on the amounts of pancreatic and liver fat…